….. “Kayani will want to hear that the United States has turned the page on past ISI operations,” it said. General Kayani was probably referring to the peace accords with the Taliban from 2004 to 2007 that resulted in the strengthening of the militants.

If the general seems confidently in charge, the cables portray Mr. Zardari as a man not fully aware of his weakness.

At one point he said he would not object if Abdul Qadeer Khan, revered in Pakistan as the father of its nuclear weapons program, were interviewed by the International Atomic Energy Agency but tacitly acknowledged that he was powerless to make that happen.

Mr. Zardari, who spent 11 years in prison on ultimately unproved corruption charges, feared for his position and possibly — the wording is ambiguous — his life: the cables reveal that Vice President Biden told Prime Minister Gordon Brownof Britain in March 2009 that Mr. Zardari had told him that the “ISI director and Kayani will take me out.”

His suspicions were not groundless. In March 2009, a period of political turmoil, General Kayani told the ambassador that he “might, however reluctantly,” pressure Mr. Zardari to resign and, the cable added, presumably leave Pakistan. He mentioned the leader of a third political party, Asfandyar Wali Khan, as a possible replacement.

“Kayani made it clear regardless how much he disliked Zardari he distrusted Nawaz even more,” the ambassador wrote, a reference to Nawaz Sharif, a former prime minister.

By 2010, after many sessions with Mr. Zardari, Ms. Patterson had revised the guarded optimism that characterized her early cables about Mr. Zardari.

“Pakistan’s civilian government remains weak, ineffectual and corrupt,” she wrote on Feb. 22, 2010, the eve of a visit by the F.B.I. director, Robert S. Mueller III. “Domestic politics is dominated by uncertainty about the fate of President Zardari.”

That assessment holds more than eight months later, even as Mr. Obama in October extended an invitation to the Mr. Zardari leader to visit the White House next year, as the leader of a nation that holds a key to peace in Afghanistan but appears too divided and mistrustful to turn it for the Americans.